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Stanford University may have a cure for Alzheimer's disease

mark_alfred
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Joined: Jan 3 2004

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mark_alfred
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Joined: Jan 3 2004

Good news from Stanford University:

Quote:
A drug which boosts the brain's immune response may prevent or cure Alzheimer's disease, scientists believe

 

http://www.telegraph.co.uk/news/science/science-news/11280504/Has-Stanfo...


Timebandit
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Joined: Sep 25 2001

It's a study of mice.  It's a promising finding, but a long, long way from a "cure".  Here's a more balanced article:

http://med.stanford.edu/news/all-news/2014/12/blocking-receptor-in-brain...

I hate it when science writers inflate findings and then say they mean something they don't.  No one at Stanford is claiming to have a cure at this point.


mark_alfred
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Joined: Jan 3 2004

Don't knock mice.  They're very similar to us.  Now excuse me, I'm off to eat some cheese.


Timebandit
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Joined: Sep 25 2001

I'm not knocking mice, just hack journalism.  Srsly, read the Stanford article, they don't have a cure - although they might have a better understanding of the disease now.  Maybe.  If, in fact, mice and humans are similar enough in this respect, which we won't know for quite some time.


mark_alfred
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Joined: Jan 3 2004

Thx, I'll check out the Stanford article.


josh
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Joined: Aug 5 2002
Seems more like a possible forestalling than a cure.

rhubarb
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Joined: Oct 6 2013

mark_alfred wrote:

Don't knock mice.  They're very similar to us.  Now excuse me, I'm off to eat some cheese.

Laughing


tducey1
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Joined: Nov 12 2010

Anything that can be done to help those with Alzheimers is a help for sure.


Unionist
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Joined: Dec 11 2005

josh wrote:
Seems more like a possible forestalling than a cure.

Forestall long enough, and it's a cure - something else will kill you first.


alan smithee
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Joined: Jan 7 2010

Anything that will lead to a cure or control of that disease is indeed good news.

Of course we're a few miles away simply because scientists still don't understand the workings of the human brain.

Imagine if we invested with the millions (billions) we waste on the drug war and the Middle East. IMO,finding cures for debilitating diseases which affect ALL of us should be a priority.

But that would be common sense and the government is run by incompetent assholes armed with an agenda.


Timebandit
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Joined: Sep 25 2001

tducey1 wrote:

Anything that can be done to help those with Alzheimers is a help for sure.

I'm not sure it's something that will help those who already have Alzheimer's - the study discovered more about what the process of Alzheimer's disease is, and may have some implications for prevention.  From the Stanford website's write-up:

Quote:

The study, published online Dec. 8 in The Journal of Clinical Investigation, illustrates the importance of microglia and could lead to new ways of warding off the onset of Alzheimer’s disease, which is predicted to afflict 15 million people by mid-century unless some form of cure or prevention is found. The study also may help explain an intriguing association between aspirin and reduced rates of Alzheimer’s.

Microglia, which constitute about 10-15 percent of all the cells in the brain, actually resemble immune cells considerably more than they do nerve cells.

“Microglia are the brain’s beat cops,” said Katrin Andreasson, MD, professor of neurology and neurological sciences and the study’s senior author. “Our experiments show that keeping them on the right track counters memory loss and preserves healthy brain physiology.”

The study itself was based on what they found in petri dishes and experiments with genetically engineered mice who had solutions injected into their brains.  It's a long way away from any kind of human application or experimentation. 

Quote:

The experiments began in a dish. Isolating viable microglia from the brain is quite difficult. But it’s easy to harvest large numbers of their close cousins, immune cells called macrophages. These cells circulate throughout the body and can be readily obtained from a blood sample. While not carbon copies of one another, microglia and macrophages share numerous genetic, biochemical and behavioral features.

When placed in a dish with soluble A-beta clusters, macrophages drawn from young mice responded calmly, producing recruiting chemicals and not ramping up production of inflammatory molecules. Notably, the output of A-beta-chewing enzymes in these young cells was robust. But macrophages from older mice acted differently: A-beta’s presence incited a big increase in EP2 activity in these cells, resulting in amped-up output of inflammatory molecules and reduced generation of recruiting chemicals and A-beta-digesting enzymes.

This early hint that age-related changes in EP2 action in microglia might be promoting some of the neuropathological features implicated in Alzheimer’s was borne out in subsequent experiments for which Andreasson’s team used mice genetically predisposed to get the mouse equivalent of Alzheimer’s, as well as otherwise normal mice into whose brains the scientists injected either A-beta or a control solution. In both groups of mice, the expected deleterious effects on memory and learning didn’t arise if EP2 within microglial cells was absent, as a result of a genetic manipulation. Blocking microglial EP2 activity significantly improved these animals’ performance on two kinds of standard memory tests: one that assesses how quickly a mouse forgets that it has encountered an object before, and another that rates the mouse’s ability to remember where a food reward is in a maze.

While I agree that far more money should be put into this line of study as well as other medical studies for diseases like MS and ALS, etc, there's also the factor of time.  It often takes years to go through the scientific process to find new treatments for diseases like Alzheimers. 


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